The Girl Who Invented Kissing follows the life of a nameless, pill-popping drifter (Suki Waterhouse) who steps off a bus and into a neighbourhood bar owned by two middle-age brothers Jimmy (Vincent Piazza) and Victor (Dash Mihok). She quickly befriends older brother Victor, a good-natured simple man with learning disabilities. The mysterious girl soon upsets the delicate balance of the brothers' lives while bringing both trouble and new life into the world of these resigned characters.